Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000108
UniProt IDP39687
Primary gene name(s)ANP32A
Synonym gene name(s)C15orf1, LANP, MAPM, PHAP1
Protein nameAcidic leucine-rich nuclear phosphoprotein 32 family member A
Protein functionImplicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation, tumor suppressor, inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT, inhibitor of histone acetyltransferases complex. Plays a role in E4F1-mediated transcriptional repression. {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:17557114}.
Subcellular locationNucleus. Cytoplasm. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the process of neuritogenesis, By similarity. Shuttles between nucleus and cytoplasm. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P39687
Gene Ontology
(Biological Process)
Complete annatation
intracellular signal transduction [GO:0035556];
nucleocytoplasmic transport [GO:0006913];
regulation of apoptotic process [GO:0042981];
regulation of mRNA stability [GO:0043488];
regulation of transcription, DNA-templated [GO:0006355];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
poly(A RNA binding [GO:0044822]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
endoplasmic reticulum [GO:0005783];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
perinuclear region of cytoplasm [GO:0048471]
Protein-protein interaction113791
Phylogenetic treeP39687
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.092922248309740.0009519294068236480.00347986418133544
AZA vs. DISU-0.3090183720261380.2220374013317880.811184149496501
AZA vs. IL70.2313112255191940.2287544465596210.989265982093417
AZA vs. SAHA0.1400335240631180.5656724660060130.854232293385558
DISU vs. CD3-1.414277110311350.0001272212610572420.000699647314548292
DISU vs. IL70.531139535917240.03533893225894290.246203175142892
DISU vs. SAHA0.4504188435396270.1227229970414040.44985749680508
DMSO vs. AZA-0.01405360868997430.9331225154338641
DMSO vs. CD3-1.116150036567810.0005536344141711110.00204474195868786
DMSO vs. DISU0.2937589543121170.2286867404907320.741620223627141
DMSO vs. IL70.2523137363823310.1604202892680460.666759266808878
DMSO vs. SAHA0.1468093268895530.5332143107179130.830053079712082
HIV vs. Mock in Activation0.04715588558931040.9395430199499420.999983755607037
HIV vs. Mock in Latency-0.04934281610713750.7649061965328740.999834320637052
IL7 vs. CD3-0.8541602613291880.008203703259886290.0253182676568931
SAHA vs. CD3-0.977241326304190.006045143378394570.0167832515231921
SAHA vs. IL7-0.09430528748914810.6983136731981580.859928135755987
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -1.221265454
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.298069 0.0436107
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.114 0.917 0.902 0.878 0.93
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
0.56 0.0003 0.03 0.1376 -0.1 0.3304 Cell growth and proliferation at 4 hpi
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2JE0 X-ray 2.4Å A/B/C/D/E/F=1-149.
2JE1 X-ray 2.6Å A/B/C/D=1-149.
4XOS X-ray 1.5Å A/B=1-149.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Rev interacts with 22174317

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found