Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000099
UniProt IDO75179
Primary gene name(s)ANKRD17
Synonym gene name(s)GTAR, KIAA0697
Protein nameAnkyrin repeat domain-containing protein 17
Protein functionCould play pivotal roles in cell cycle and DNA regulation, PubMed:19150984. Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways, PubMed:22328336. Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too, PubMed:23711367. Target of enterovirus 71 which is the major etiological agent of HFMD, hand, foot and mouth disease, PubMed:17276651. Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system, By similarity. {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:22328336}. Nucleus {ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336}. Note=Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner. {ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O75179
Gene Ontology
(Biological Process)
Complete annatation
blood vessel maturation [GO:0001955];
defense response to bacterium [GO:0042742];
innate immune response [GO:0045087];
negative regulation of smooth muscle cell differentiation [GO:0051151];
positive regulation of cell cycle [GO:0045787];
positive regulation of G1/S transition of mitotic cell cycle [GO:1900087];
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123];
positive regulation of MDA-5 signaling pathway [GO:1900245];
positive regulation of RIG-I signaling pathway [GO:1900246];
regulation of DNA replication [GO:0006275];
viral process [GO:0016032]
Gene Ontology
(Molecular Function)
Complete annatation
chromatin binding [GO:0003682];
poly(A RNA binding [GO:0044822]
Gene Ontology
(Cellular Component)
Complete annatation
chromatin [GO:0000785];
cytoplasm [GO:0005737];
membrane [GO:0016020];
nucleus [GO:0005634]
Protein-protein interaction117519
Phylogenetic treeO75179
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.3383252218653560.3041887970568530.422750903572235
AZA vs. DISU0.2530882139617740.3170576440598420.869402233685592
AZA vs. IL70.09683039178771710.6138581821550860.999311006273513
AZA vs. SAHA0.05444034074744060.8231453873709430.956625255596125
DISU vs. CD3-0.09787020058009840.7895416118406770.855078979733842
DISU vs. IL7-0.1651496319836240.51168405155890.832745464428686
DISU vs. SAHA-0.1975286381782080.4982564705610280.823605289159996
DMSO vs. AZA0.004382301130451540.9790857156339191
DMSO vs. CD3-0.3450215220166390.2837819764369550.392794512589372
DMSO vs. DISU-0.250518454516040.3043558055623550.811498856723186
DMSO vs. IL70.09973801311587680.5783600676614320.905672503991634
DMSO vs. SAHA0.04282465091017550.8556642320965960.962065210953402
HIV vs. Mock in Activation0.3007493738492710.6315799053113140.999983755607037
HIV vs. Mock in Latency0.03914560019714170.8120143294600140.999834320637052
IL7 vs. CD3-0.2338030856582040.4699389962728970.602216934923356
SAHA vs. CD3-0.3089618513687730.3833738293064090.499995119657947
SAHA vs. IL7-0.04629659558822940.849057321307430.936466676036306
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0705968 0.684664
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.86 1.031 0.903 0.824 1.014
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpr interacts with 22190034
HIV-1 virus replication enhanced by expression of human gene 19460752

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found