Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000081
UniProt IDP30837
Primary gene name(s)ALDH1B1
Synonym gene name(s)ALDH5, ALDHX
Protein nameAldehyde dehydrogenase X, mitochondrial
Protein functionALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
Subcellular locationMitochondrion matrix.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P30837
Gene Ontology
(Biological Process)
Complete annatation
carbohydrate metabolic process [GO:0005975];
ethanol catabolic process [GO:0006068];
ethanol oxidation [GO:0006069]
Gene Ontology
(Molecular Function)
Complete annatation
aldehyde dehydrogenase, NAD activity [GO:0004029]
Gene Ontology
(Cellular Component)
Complete annatation
intracellular membrane-bounded organelle [GO:0043231];
mitochondrial matrix [GO:0005759];
mitochondrion [GO:0005739];
nucleoplasm [GO:0005654]
Protein-protein interaction106721
Phylogenetic treeP30837
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.142785718934350.000750996607407850.00282340256095064
AZA vs. DISU-0.930384828225320.0004000334154681260.0424655190476516
AZA vs. IL70.577459915552240.003682282586474290.183784918628898
AZA vs. SAHA-0.2794129540920620.2697201797255910.643687965095946
DISU vs. CD3-2.083347754536248.61796219941979e-081.09074023672589e-06
DISU vs. IL71.498331362563571.27463176680109e-083.49364979718663e-06
DISU vs. SAHA0.6503374106404550.03343767206699470.220638859773063
DMSO vs. AZA0.007420962703128450.9664314713007851
DMSO vs. CD3-1.147604640092060.0005207625411115520.00193519676414542
DMSO vs. DISU0.9352370352948340.0002250825744281040.0251258844194928
DMSO vs. IL70.5776761423382720.001906599273023170.0852877864712886
DMSO vs. SAHA-0.2935931782597460.2293624239236610.575614498368867
HIV vs. Mock in Activation-0.001354959349182420.9983497314444390.999983755607037
HIV vs. Mock in Latency-0.02811485912441660.8715454358793550.999834320637052
IL7 vs. CD3-0.5566343377919060.08964349450006810.17394392283722
SAHA vs. CD3-1.448543346564396.52067001116752e-050.000328633803792696
SAHA vs. IL7-0.8612515095059440.000623110416846040.00816819808206488
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
-0.4452 0.0191

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.262376 0.062176
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.986 0.902 0.915 0.823 0.747
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00157 NADH nutraceutical unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human)
hsa00053 Ascorbate and aldarate metabolism - Homo sapiens (human)
hsa00071 Fatty acid degradation - Homo sapiens (human)
hsa00280 Valine# leucine and isoleucine degradation - Homo sapiens (human)
hsa00310 Lysine degradation - Homo sapiens (human)
hsa00330 Arginine and proline metabolism - Homo sapiens (human)
hsa00340 Histidine metabolism - Homo sapiens (human)
hsa00380 Tryptophan metabolism - Homo sapiens (human)
hsa00410 beta-Alanine metabolism - Homo sapiens (human)
hsa00561 Glycerolipid metabolism - Homo sapiens (human)
hsa00620 Pyruvate metabolism - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
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