Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000064
UniProt IDO00116
Primary gene name(s)AGPS
Synonym gene name(s)unknown
Protein nameAlkyldihydroxyacetonephosphate synthase, peroxisomal
Protein functionCatalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids. {ECO:0000250}.
Subcellular locationPeroxisome membrane. Note=Localized to the inner aspect of the peroxisomal membrane.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O00116
Gene Ontology
(Biological Process)
Complete annatation
ether lipid biosynthetic process [GO:0008611];
lipid biosynthetic process [GO:0008610]
Gene Ontology
(Molecular Function)
Complete annatation
alkylglycerone-phosphate synthase activity [GO:0008609];
FAD binding [GO:0071949];
oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]
Gene Ontology
(Cellular Component)
Complete annatation
intracellular membrane-bounded organelle [GO:0043231];
membrane [GO:0016020];
mitochondrion [GO:0005739];
nucleolus [GO:0005730];
peroxisomal matrix [GO:0005782];
peroxisomal membrane [GO:0005778];
peroxisome [GO:0005777]
Protein-protein interaction114110
Phylogenetic treeO00116
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.007586522317760.002282547608752130.00741594256501661
AZA vs. DISU0.02815051521833350.9113966350308520.994271142470137
AZA vs. IL70.3110823671420530.1061330879364750.850475297430347
AZA vs. SAHA-0.1250252312565970.6084494496492890.871675252234687
DISU vs. CD3-0.9922522017287720.006621754986542380.0205590718680915
DISU vs. IL70.2742886290063020.2763049470974910.663590619592675
DISU vs. SAHA-0.1527557999528440.6000718729979760.872437121160766
DMSO vs. AZA-0.1147539005969750.4942124822752171
DMSO vs. CD3-1.132791473933470.0004594627915106560.00173373381944806
DMSO vs. DISU-0.144592825860030.5535696153553070.923674030044315
DMSO vs. IL70.4330475433850740.01628596394522090.266280809624951
DMSO vs. SAHA-0.0181289079424860.9387231431809910.985064509878897
HIV vs. Mock in Activation0.1273256238345990.8379636600001750.999983755607037
HIV vs. Mock in Latency0.04865095005639510.7685408848303040.999834320637052
IL7 vs. CD3-0.6875930056637830.03287849843217440.0783997784185988
SAHA vs. CD3-1.158242242523120.001192422572922510.00415582982746121
SAHA vs. IL7-0.4402347700293670.07112002642308510.232635742334935
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -1.128099489
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.00311676 0.98866
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.99 0.995 1.053 1.1 0.961
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpr interacts with 22190034
capsid interacts with 25505242

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00565 Ether lipid metabolism - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa04146 Peroxisome - Homo sapiens (human)