Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000049
UniProt IDP29275
Primary gene name(s)ADORA2B
Synonym gene name(s)unknown
Protein nameAdenosine receptor A2b
Protein functionReceptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular locationCell membrane;
Multi-pass membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P29275
Gene Ontology
(Biological Process)
Complete annatation
activation of adenylate cyclase activity [GO:0007190];
activation of MAPK activity [GO:0000187];
adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189];
cellular defense response [GO:0006968];
cellular protein metabolic process [GO:0044267];
cellular response to extracellular stimulus [GO:0031668];
excretion [GO:0007588];
G-protein coupled receptor signaling pathway [GO:0007186];
JNK cascade [GO:0007254];
positive regulation of chemokine production [GO:0032722];
positive regulation of chronic inflammatory response to non-antigenic stimulus [GO:0002882];
positive regulation of guanylate cyclase activity [GO:0031284];
positive regulation of interleukin-6 production [GO:0032755];
positive regulation of mast cell degranulation [GO:0043306];
positive regulation of vascular endothelial growth factor production [GO:0010575];
relaxation of vascular smooth muscle [GO:0060087]
Gene Ontology
(Molecular Function)
Complete annatation
G-protein coupled adenosine receptor activity [GO:0001609]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of plasma membrane [GO:0005887];
intracellular [GO:0005622];
plasma membrane [GO:0005886]
Protein-protein interaction106648
Phylogenetic treeP29275
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.399019024132490.001007608360270140.00366032133188517
AZA vs. DISU-0.1908749915793360.4997563316952330.93488174988874
AZA vs. IL7-0.1837134555043250.4307801007813750.999311006273513
AZA vs. SAHA0.05616556420755730.8583341755366850.967133804138028
DISU vs. CD3-1.603858178643590.0001143648630711480.000638731361961647
DISU vs. IL70.0001091784587831920.999676591491940.999957156847617
DISU vs. SAHA0.2470877184547640.4227738573119150.775678559770573
DMSO vs. AZA-0.0475435771757960.8777224471759731
DMSO vs. CD3-1.462409650132920.0006137992326579190.00223246872042288
DMSO vs. DISU0.1404015632623540.6232278054049620.944230759391396
DMSO vs. IL7-0.1271381670574980.5943741605734390.911051395083334
DMSO vs. SAHA0.09653225539302120.7607746251250580.93064423709115
HIV vs. Mock in Activation0.2390156223603920.7573504588904770.999983755607037
HIV vs. Mock in Latency-0.1784144278562150.3468530649802330.999834320637052
IL7 vs. CD3-1.575663356963552.97488306404414e-050.000201620559461949
SAHA vs. CD3-1.370003697336970.00154147907945090.00519456389251456
SAHA vs. IL70.2324283087740620.3806634647278190.631395363920239
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.45547 0.00864647
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00277 Theophylline approved yes antagonist
DB00824 Enprofylline approved yes antagonist
DB04932 Defibrotide approved, investigational unknown unknown
DB00640 Adenosine approved, investigational yes agonist

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04015 Rap1 signaling pathway - Homo sapiens (human)
hsa04020 Calcium signaling pathway - Homo sapiens (human)
hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
hsa05034 Alcoholism - Homo sapiens (human)