Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000010
UniProt IDO15440
Primary gene name(s)ABCC5
Synonym gene name(s)MRP5
Protein nameMultidrug resistance-associated protein 5
Protein functionActs as a multispecific organic anion pump which can transport nucleotide analogs. {ECO:0000269|PubMed:10840050}.
Subcellular locationMembrane;
Multi-pass membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O15440
Gene Ontology
(Biological Process)
Complete annatation
hyaluronan biosynthetic process [GO:0030213];
transmembrane transport [GO:0055085];
transport [GO:0006810]
Gene Ontology
(Molecular Function)
Complete annatation
anion transmembrane-transporting ATPase activity [GO:0043225];
ATP binding [GO:0005524];
organic anion transmembrane transporter activity [GO:0008514]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of plasma membrane [GO:0005887];
membrane [GO:0016020];
plasma membrane [GO:0005886]
Protein-protein interaction115368
Phylogenetic treeO15440
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.6296367954879450.05592368601812340.109707379365502
AZA vs. DISU0.1010988541188880.6906303302546750.968313969505284
AZA vs. IL7-0.2701070759779090.1636911101600770.930759564799561
AZA vs. SAHA-0.3496288781989690.4451362665100250.789502774605496
DISU vs. CD30.7166924243321110.04972031820104760.107380572204311
DISU vs. IL7-0.380928333010660.1326430772518560.475928739259032
DISU vs. SAHA-0.4478456174461910.3387307852388120.717888423324405
DMSO vs. AZA0.08014806705684320.6355527118454571
DMSO vs. CD30.6987787496659480.02992979319261410.0627284828111758
DMSO vs. DISU-0.022530635484020.9266908206921640.990404270889103
DMSO vs. IL7-0.343137965633050.05861157620645920.468821519029444
DMSO vs. SAHA-0.4353367892788590.3374493509680430.690469938621548
HIV vs. Mock in Activation0.4880519521645360.4352856711386040.999983755607037
HIV vs. Mock in Latency0.260493590202280.1169595833448960.999834320637052
IL7 vs. CD30.3646838341288290.2579989689316090.390875309951366
SAHA vs. CD30.2570074743293450.5823994729757790.682697577609287
SAHA vs. IL7-0.08214555339642610.8583460545591840.94071666118991
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.054163 0.838996
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB01045 Rifampicin approved unknown inducer
DB00515 Cisplatin approved unknown inducer
DB01138 Sulfinpyrazone approved unknown inhibitor
DB00203 Sildenafil approved, investigational unknown inhibitor
DB01032 Probenecid approved unknown inhibitor
DB02527 Cyclic Adenosine Monophosphate experimental unknown inhibitor
DB00975 Dipyridamole approved unknown inhibitor
DB00917 Dinoprostone approved unknown inhibitor
DB00770 Alprostadil approved, investigational unknown inhibitor
DB00718 Adefovir Dipivoxil approved, investigational unknown substrate
DB01033 Mercaptopurine approved unknown substrate
DB00143 Glutathione approved, nutraceutical unknown substrate
DB01076 Atorvastatin approved unknown substrate
DB00495 Zidovudine approved unknown substrate
DB00544 Fluorouracil approved unknown substrate

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa01523 Antifolate resistance - Homo sapiens (human)
hsa02010 ABC transporters - Homo sapiens (human)