Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000009
UniProt IDQ5T3U5
Primary gene name(s)ABCC10
Synonym gene name(s)MRP7, SIMRP7
Protein nameMultidrug resistance-associated protein 7
Protein functionATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion. {ECO:0000269|PubMed:12527806, ECO:0000269|PubMed:15256465}.
Subcellular locationCell membrane {ECO:0000269|PubMed:12566991, ECO:0000269|PubMed:15256465};
Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:12566991, ECO:0000269|PubMed:15256465}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q5T3U5
Gene Ontology
(Biological Process)
Complete annatation
transmembrane transport [GO:0055085]
Gene Ontology
(Molecular Function)
Complete annatation
anion transmembrane-transporting ATPase activity [GO:0043225];
ATP binding [GO:0005524]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of membrane [GO:0016021];
lysosomal membrane [GO:0005765];
plasma membrane [GO:0005886]
Protein-protein interaction124617
Phylogenetic treeQ5T3U5
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.065588939612820.0013402483118240.00469009114367572
AZA vs. DISU-0.2127107359197180.4038110588578650.905545478540778
AZA vs. IL7-0.0744041424695460.7002532832609410.999311006273513
AZA vs. SAHA-0.3263500524312170.1835222030626020.546756745960874
DISU vs. CD30.8399716355116330.02154273920034230.0547706612760938
DISU vs. IL70.1284533000307150.6249929832254090.886561488082343
DISU vs. SAHA-0.1107881491845660.7074314143529390.913563472598201
DMSO vs. AZA0.1626695983108530.3347970444936681
DMSO vs. CD31.215871343305760.0001879134032249930.000785825398370029
DMSO vs. DISU0.3733571499839730.1291818861048560.617826411805833
DMSO vs. IL7-0.2295797334333120.2040651940345410.714647998878565
DMSO vs. SAHA-0.493751920887590.03739373570860520.211944712622937
HIV vs. Mock in Activation0.2971492066531830.6343907098569650.999983755607037
HIV vs. Mock in Latency0.1557284506574930.3483162900706770.999834320637052
IL7 vs. CD30.9960776347871670.002236591212159910.00848082032428595
SAHA vs. CD30.7161907038716160.04542889041387640.0916238461639612
SAHA vs. IL7-0.2545195975247490.2981340390297830.5469344366878
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.332678 0.020997
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00541 Vincristine approved, investigational unknown substrate
DB00661 Verapamil approved unknown inhibitor
DB01229 Paclitaxel approved, vet_approved unknown substrate
DB04348 Taurocholic Acid experimental unknown inhibitor
DB00203 Sildenafil approved, investigational unknown inhibitor
DB00563 Methotrexate approved unknown inhibitor
DB00773 Etoposide approved unknown substrate
DB00997 Doxorubicin approved, investigational unknown inhibitor
DB00091 Cyclosporine approved, investigational, vet_approved unknown inhibitor
DB00783 Estradiol approved, investigational, vet_approved unknown inhibitor
DB00987 Cytarabine approved, investigational unknown substrate
DB00694 Daunorubicin approved unknown substrate
DB01248 Docetaxel approved, investigational unknown substrate
DB00441 Gemcitabine approved unknown substrate
DB00300 Tenofovir approved, investigational unknown substrate

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa02010 ABC transporters - Homo sapiens (human)