Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000008
UniProt IDQ8IZY2
Primary gene name(s)ABCA7
Synonym gene name(s)unknown
Protein nameATP-binding cassette sub-family A member 7
Protein functionPlays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. {ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867, ECO:0000269|PubMed:14592415}.
Subcellular locationCell membrane {ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:14592415};
Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q91V24};
Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q91V24};
Multi-pass membrane protein {ECO:0000255}. Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney, By similarity. Isoform 2 may localize to the endoplasmic reticulum, PubMed:14592415. {ECO:0000250|UniProtKB:Q91V24, ECO:0000269|PubMed:14592415}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q8IZY2
Gene Ontology
(Biological Process)
Complete annatation
apolipoprotein A-I-mediated signaling pathway [GO:0038027];
cholesterol efflux [GO:0033344];
high-density lipoprotein particle assembly [GO:0034380];
memory [GO:0007613];
negative regulation of amyloid precursor protein biosynthetic process [GO:0042985];
negative regulation of beta-amyloid formation [GO:1902430];
peptide cross-linking [GO:0018149];
phagocytosis [GO:0006909];
phospholipid efflux [GO:0033700];
phospholipid translocation [GO:0045332];
positive regulation of beta-amyloid clearance [GO:1900223];
positive regulation of cholesterol efflux [GO:0010875];
positive regulation of engulfment of apoptotic cell [GO:1901076];
positive regulation of ERK1 and ERK2 cascade [GO:0070374];
positive regulation of phagocytosis [GO:0050766];
positive regulation of phospholipid efflux [GO:1902995];
protein localization to nucleus [GO:0034504];
transmembrane transport [GO:0055085]
Gene Ontology
(Molecular Function)
Complete annatation
apolipoprotein A-I receptor activity [GO:0034188];
ATPase activity, coupled to transmembrane movement of substances [GO:0042626];
ATP binding [GO:0005524];
phospholipid transporter activity [GO:0005548];
transporter activity [GO:0005215]
Gene Ontology
(Cellular Component)
Complete annatation
apical plasma membrane [GO:0016324];
ATP-binding cassette, ABC transporter complex [GO:0043190];
cell junction [GO:0030054];
cell surface [GO:0009986];
early endosome membrane [GO:0031901];
Golgi apparatus [GO:0005794];
Golgi membrane [GO:0000139];
integral component of membrane [GO:0016021];
intracellular membrane-bounded organelle [GO:0043231];
phagocytic cup [GO:0001891];
plasma membrane [GO:0005886];
ruffle membrane [GO:0032587]
Protein-protein interaction115629
Phylogenetic treeQ8IZY2
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-4.28765914077728.74749161994259e-101.28002129801723e-08
AZA vs. DISU0.1669188466001610.5798116824825130.954982272511679
AZA vs. IL7-0.6055177227628610.02970214859859880.540701069838985
AZA vs. SAHA0.7831059086968110.006639144919153290.074492119956802
DISU vs. CD34.441326422551321.09607378728782e-092.17684008821826e-08
DISU vs. IL7-0.78208733968930.02255689644762090.190501520418984
DISU vs. SAHA0.6194706055457630.07929369577174080.357496427923882
DMSO vs. AZA0.02677575695467860.8897273674764591
DMSO vs. CD34.300921677502253.8911929234331e-105.47346604962835e-09
DMSO vs. DISU-0.1423659692432190.6055096814207320.939289650701039
DMSO vs. IL7-0.6246421278516610.01222039969133930.233193070059417
DMSO vs. SAHA0.7518426341169020.003301098933691680.0412527877526263
HIV vs. Mock in Activation0.9249274852046190.4709794987411850.999983755607037
HIV vs. Mock in Latency-0.02986681797690780.8564238720102930.999834320637052
IL7 vs. CD33.686202894655711.83330307046425e-072.11912401695611e-06
SAHA vs. CD35.046327368929717.25911553089986e-111.61111739397144e-09
SAHA vs. IL71.385188633807174.17590791940148e-050.000971414135448424
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
0.6319 0.03648

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.429465 0.0456212
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa02010 ABC transporters - Homo sapiens (human)